Can You Overdose on Flexeril? Side Effects & Symptoms

Many insurance companies require prior authorization for this drug. This means your doctor will need to get approval from your insurance company flexeril ingredients before your insurance company will pay for the prescription. You should not need a new prescription for this medication to be refilled.

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It also increases the risk of abusing the substance, which may lead to dependence forming. While the maximum dose of Cyclobenzaprine is 3 X 10mg daily, it is not advised to take this dose at once, or even 2 x 10mg in one dose. Since overdosage is often deliberate, patients may attempt suicide by other means during the recovery phase.

If you experience any of the following symptoms, call your doctor immediately:

Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Cyclobenzaprine has mild interactions with at least 221 different drugs. Cyclobenzaprine has moderate interactions with at least 43 different drugs. RxList does not provide medical advice, diagnosis or treatment.

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The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine.

Clinical Pharmacology

VLD CBP treatment decreased Stage 4 EEG nonREM sleep and decreased REM, which is not consistent with either increased Stage 4 or REM serving as surrogates for refreshing sleep. The CBP products currently marketed for treating muscle spasm are not designed for bedtime use. The immediate-release product Flexeril® is recommended for tid dosing (5 mg or 10 mg tablets tid), which results in relatively stable blood levels over 24 hours after several days of treatment10. The controlled-release CBP product Amrix® mimics, and flattens, the pharmacokinetic profile of tid immediate-release CBP, so that bedtime administration of Amrix results in only a modest increase in nighttime blood levels11. Consequently, achieving high nighttime and low daytime blood levels of CBP requires bedtime dosing of immediate-release CBP formulations.

The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation.

• Higher doses of cyclobenzaprine or tizanidine would be appropriate to promote sedation in cases of more severe discomfort or perceived muscular spasm.
• In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration.
• Skeletal muscle relaxants are often prescribed for musculoskeletal conditions including low back pain, neck pain, fibromyalgia, tension headaches, and myofascial pain syndrome.
• Physical examination data were listed, and any new physical findings were summarized.
• The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, PHARMACOKINETICS, ELDERLY).

The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed. In such patients cyclobenzaprine should be initiated with a 5 mg dose and titrated slowly upward. The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly). The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed.

What should I know about storage and disposal of this medication?

It has a half-life of 18 hours so it will stay in the body for about 90 hours. This means it will show up on drug tests for nearly 4 days. If a person has liver or kidney problems, the drug may remain in the body for longer. This is because the liver will take longer to process the drug through. It’s important that someone on Flexeril let the test administrator know they’re taking Flexeril.

Secondary endpoints included a physician’s evaluation of the presence and extent of palpable muscle spasm. In order to protect against the rare but potentially critical manifestations described above, obtain an ECG and immediately initiate cardiac monitoring. Protect the patient’s airway, establish an intravenous line and initiate gastric decontamination. Observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required.

The combination of Flexeril and alcohol can cause serious problems in the central nervous system, the consequences of which may end up being fatal. The problem with combining Flexeril and alcohol comes from the fact that both of these drugs are actually central nervous system (CNS) depressants. That means that both Flexeril and alcohol have a tendency to slow down the body’s natural processes. One of the most important bodily processes that these two drugs can end up impacting is respiration. When used alone, alcohol can end up slowing respiration to deadly levels due to alcohol poisoning. Flexeril abuse can also end up leading to dangerously slow respiration.